What is the final rounded dose of Cisplatin for a patient with an area of 1.862 m²?

To determine the correct final rounded dose of Cisplatin based on the patient's body surface area (BSA), a standard dosing formula is typically used. The usual dose of Cisplatin is approximately 50-75 mg/m² for treating cancer.

For this patient with a BSA of 1.862 m², if we calculate the dose using the middle value of the dosing range, let's take 75 mg/m² as a reference.

We would calculate the total dose as follows:

• Total dose = BSA × Dose per m²
• Total dose = 1.862 m² × 75 mg/m²

This results in:

• Total dose = 139.65 mg

When converting this to grams for clarity:

• 139.65 mg = 0.13965 g

Rounding this to three significant figures gives us approximately 0.140 g.

However, if instead, we were to calculate using a lower dose (for instance, 20 mg/m², which can also be common), the calculation would be:

• Total dose = 1.862 m² × 20 mg/m²
• Total dose = 37.24 mg = 0.03724 g